N-{6-[(Phenylmethyl)oxy]-3-pyridinyl}acetamide → HCID 178474274、化合物
反応式
C1(C[O:8][C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[N:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=1参加物
4
実験手順
To a solution of N-{6-[(phenylmethyl)oxy]-3-pyridinyl}acetamide (0.210 g, 0.87 mmol) in EtOH (10 mL) at rt was added Pd—C (0.046 g of 10 wt % on activated carbon (dry basis), ca. 50 wt % H2O; ca. 0.022 mmol Pd). The mixture was placed under an atmosphere of H2 and stirred for 4.5 h. The mixture was filtered through Celite (EtOAc wash) and concentrated in vacuo, affording 0.132 g of the title compound as a colorless solid: MS (ESI) m/z 152 (M+).
後処理
- filtrationThe mixture was filtered through Celite (EtOAc wash)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-6253c988063c46f6b92abd8d073f19a3
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834063B2
反応ノート
読み込み中…