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Acetic Acid → 2-{4-[(4-Dipropylaminomethylphenylamino)methyl]benzyl}isoindole-1,3-dione

HRID 1173885
ノート
印刷プレビュー

反応式

HRID 1173885 の反応式
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1.[CH2:21]([N:24]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1)[CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23].C([BH3-])#N.[Na+].C(O)(=O)C>CO.O>[CH2:21]([N:24]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([NH:35][CH2:17][C:16]2[CH:15]=[CH:14][C:13]([CH2:12][N:3]3[C:4](=[O:11])[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[C:2]3=[O:1])=[CH:20][CH:19]=2)=[CH:31][CH:30]=1)[CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 176Acetic AcidHCID 5003444Sodium cyanoborohydrideHCID 167770114-Dipropylaminomethyl-anilineHCID 231555474-(1,3-Dioxo-1,3-dihydroisoindol-2-ylmethyl)benzaldehyde

生成物 1

HCID 210843762-{4-[(4-Dipropylaminomethylphenylamino)methyl]benzyl}isoindole-1,3-dione収率 250.1%

試薬・触媒・溶媒 2

HCID 887
Methanol
溶媒
HCID 962Water溶媒

実験手順

The compound (17.6 mg) obtained in Example 25-1, the compound (13.2 mg) obtained in Example 19-2, and sodium cyanoborohydride (8.7 mg) were dissolved in anhydrous methanol (1.0 ml). The solution was then adjusted to pH 5 with the addition of acetic acid, followed by stirring at room temperature for 4 hours. The reaction solution was added with distilled water and then subjected to extraction with chloroform. After that, the organic layer was washed with saturated saline solution and dried with anhydrous sodium sulfate. The solvent was distilled off and the residue was then purified through silica gel preparative thin-layer chromatography (chloroform/methanol), thereby obtaining the subject compound (72.9 mg) as a yellow solid.

後処理

  1. extractionsubjected to extraction with chloroform
  2. washAfter that, the organic layer was washed with saturated saline solution
  3. dry with materialdried with anhydrous sodium sulfate
  4. distillationThe solvent was distilled off
  5. customthe residue was then purified through silica gel preparative thin-layer chromatography (chloroform/methanol)

出典と根拠

ORDレコード
ord-b707b18300b640c9a6709d8d62fd68b7
出典データセット
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07833991B2

反応ノート

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