1-(Hydroxymethyl)isoquinoline → Isoquinoline-1-carbaldehyde

HRID 1173911ノート

反応式

HRID 1173911 の反応式
[C:1]1([CH2:11][OH:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([CH:11]=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

参加物

4

反応物 1

HCID 27762471-(Hydroxymethyl)isoquinoline

生成物 1

HCID 265306Isoquinoline-1-carbaldehyde収率 85.1%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

Isoquinolin-1-yl-methanol (123.7 mg) was dissolved in chloroform (6.2 ml) and then added with manganese dioxide (chemically processed product) (1.24 g), followed by stirring at room temperature for 30 minutes. The reaction solution was filtrated through Celite and the solvent was then distilled off. The residue was dried under vacuum, thereby obtaining the subject compound (103.9 mg) as a brown solid.

後処理

  1. filtrationThe reaction solution was filtrated through Celite
  2. distillationthe solvent was then distilled off
  3. customThe residue was dried under vacuum

出典と根拠

ORDレコード
ord-b1e070c7986146688b54b66074608f16
出典データセット
uspto-grants-2010_11
特許番号
US07833991B2

反応ノート

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