ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Methanol → 3-(6-t-Butyldimethylsilyloxymethylnaphthalen-2-yl)propan-1-ol

HRID 1173988
ノート
印刷プレビュー

反応式

HRID 1173988 の反応式
C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH2:16][O:17][Si:18]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19])[CH:12]=2)[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].CO.C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>C1COCC1>[Si:18]([O:17][CH2:16][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]=[C:6]([CH2:5][CH2:4][CH2:3][OH:2])[CH:15]=[CH:14]2)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 887MethanolHCID 9855836Potassium sodium tartarateHCID 21226445Aluminium lithium hydrideHCID 669415313-(6-t-butyldimethylsilyloxymethylnaphthalen-2-yl)propionic Acid Methyl Ester

生成物 1

HCID 230791693-(6-t-Butyldimethylsilyloxymethylnaphthalen-2-yl)propan-1-ol収率 109.3%

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

The compound (2.62 g) obtained in Example 121-5 was dissolved in anhydrous THF (100 ml) and added with lithium aluminum hydride (555 mg) under ice-cooling, followed by stirring for 30 minutes under a nitrogen atmosphere. After completion of the reaction, the solution was added with methanol and then added with an aqueous potassium sodium tartrate solution, followed by stirring overnight. The solution was extracted with chloroform and the extract was washed with saturate saline solution. Then, the organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off, thereby obtaining the subject compound (2.64 g) as a white solid.

後処理

  1. temperaturecooling
  2. customAfter completion of the reaction
  3. stirringby stirring overnight
  4. extractionThe solution was extracted with chloroform
  5. washthe extract was washed
  6. concentrationwith saturate saline solution
  7. dry with materialThen, the organic layer was dried with anhydrous sodium sulfate
  8. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-c17d92a3f1844dca8f23690e37d9cd27
出典データセット
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07833991B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート