Hydrazine hydrate (1:1) → [4-(5-Aminomethyl-1-methoxyindan-2-yl)-butyl]-dipropylamine
反応式
[CH2:1]([N:4]([CH2:32][CH2:33][CH3:34])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH:15]=2)[CH:10]1[O:30][CH3:31])[CH2:2][CH3:3].O.NN>CO>[NH2:19][CH2:18][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[CH:10]([O:30][CH3:31])[CH:9]([CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:32][CH2:33][CH3:34])[CH2:1][CH2:2][CH3:3])[CH2:17]2参加物
4
実験手順
The compound (95.7 mg) obtained in Example 127-12 was dissolved in methanol (4.79 ml) and added with hydrazine monohydrate (0.0957 ml), followed by thermal reflux for 1 hour. The reaction solution was concentrated under reduced pressure. Then, the residue was added with water and subjected to separation/extraction with chloroform, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (45.0 mg) as a yellow oily substance.