Dimethyl Sulfate → tert-Butylanisole

HRID 1174078ノート

反応式

HRID 1174078 の反応式
COS([O:6][CH3:7])(=O)=O.[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1O)([CH3:11])([CH3:10])[CH3:9].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)Cl>[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:6][CH3:7])([CH3:11])([CH3:10])[CH3:9]

参加物

6

反応物 3

HCID 6497Dimethyl SulfateHCID 69232-Tert-ButylphenolHCID 14798Sodium Hydroxide

生成物 1

HCID 270626tert-Butylanisole

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 6344Dichloromethane溶媒

実験手順

Dimethylsulfate (56.7 g, 0.45 mol) was added at room temperature to a well-stirred mixture of 2-tert-butylphenol (45 g, 0.3 mol), CH2Cl2 (200 ml), 40% aq. NaOH (200 ml) and tetrabutylammonium bromide (1 g). After 16 h of stirring, the organic phase was separated, washed with H2O, dried over MgSO4, evaporated and distilled at 110-112° C./10 Torr. Yield 35 g (71%).

後処理

  1. customthe organic phase was separated
  2. washwashed with H2O
  3. dry with materialdried over MgSO4
  4. customevaporated
  5. distillationdistilled at 110-112° C./10 Torr

出典と根拠

ORDレコード
ord-7b013c4d5af44a8aa3faa5907fc81757
出典データセット
uspto-grants-2010_11
特許番号
US07834205B2

反応ノート

読み込み中…