Trifluoroacetic acid → Trifluoroacetic acid

HRID 1174145ノート

反応式

HRID 1174145 の反応式
[CH3:1][C@@H:2]([CH2:24][CH3:25])[C@H:3]([N:11]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[N:18]=[C:19]([CH3:22])[S:20][CH:21]=2)[C:12]1=[O:23])[C:4]([O:6]C(C)(C)C)=[O:5].[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>ClCCl>[CH3:1][C@@H:2]([CH2:24][CH3:25])[C@H:3]([N:11]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[N:18]=[C:19]([CH3:22])[S:20][CH:21]=2)[C:12]1=[O:23])[C:4]([OH:6])=[O:5].[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 67410059tert-butyl (2S,3S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoate

生成物 2

HCID 6422Trifluoroacetic acidHCID 67407644(2s,3s)-3-Methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}pentanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

A solution containing the product from Example 11C (2.0 g, 5.4 mmol) in dichloromethane (14 mL) was treated with trifluoracetic acid (7 mL), stirred at 25° C. for 3 hours and concentrated to give the title compound as a trifluoroacetic acid salt.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-59877b69e62e4bf19817fa5f1ab2e69d
出典データセット
uspto-grants-2010_11
特許番号
US07834043B2

反応ノート

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