[OH:1][C@@H:2]([CH2:30][C@@H:31]([NH:39][C:40](=[O:51])[C@@H:41]([NH:46][C:47]([O:49][CH3:50])=[O:48])[C:42]([CH3:45])([CH3:44])[CH3:43])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C@@H:3]([NH:19]C(=O)OCC1C=CC=CC=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=2)=[CH:7][CH:6]=1.Cl>CO.[Pd]>[NH2:19][C@@H:3]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=2)=[CH:9][CH:10]=1)[C@@H:2]([OH:1])[CH2:30][C@@H:31]([NH:39][C:40]([C@@H:41]([NH:46][C:47](=[O:48])[O:49][CH3:50])[C:42]([CH3:44])([CH3:45])[CH3:43])=[O:51])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1A solution containing the product from Example 120A (0.028 g, 0.041 mmol) in methanol (1 mL) was treated with 10% Pd on carbon (0.003 g) and HCl solution (0.030 mL, 4 N in dioxane), and the reaction was stirred under a hydrogen atmosphere (balloon pressure) at 25° C. for 16 hours. The reaction was filtered through a bed of celite and rinsed with methanol. The solvent was concentrated to give the title compound as the hydrochloride salt, which was used without further purification.
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