Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine

HRID 1174960

反応式

HRID 1174960 の反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][NH2:15]>C1COCC1.O>[CH3:14][NH:15][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

参加物

5

反応物 2

HCID 6329MethylamineHCID 754762-Chloro-6-nitrobenzothiazole

生成物 1

HCID 638568N-Methyl-6-nitrobenzo[D]thiazol-2-amine収率 88%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).

後処理

  1. customprecipitates out
  2. concentrationConcentrate in vacuo
  3. customtriturate with methanol
  4. filtrationFilter off the product
  5. washwash with methanol
  6. customDry thoroughly

出典と根拠

ORDレコード
ord-d63f6ac0ae0d46888a58e608370ee763
出典データセット
uspto-grants-2010_11
特許番号
US07838543B2

関連ノート

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