Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine
反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][NH2:15]>C1COCC1.O>[CH3:14][NH:15][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1参加物
5
実験手順
Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).
後処理
- customprecipitates out
- concentrationConcentrate in vacuo
- customtriturate with methanol
- filtrationFilter off the product
- washwash with methanol
- customDry thoroughly
出典と根拠
- ORDレコード
- ord-d63f6ac0ae0d46888a58e608370ee763
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07838543B2
反応ノート
読み込み中…