Sodium Hydroxide → 2-Methyl-[1,1'-biphenyl]-4-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([CH3:17])[CH:6]=1)=[O:4].[OH-].[Na+]>CO.O>[CH3:17][C:7]1[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=[CH:9][C:8]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
A solution of 2-methyl-biphenyl-4-carboxylic acid methyl ester (0.10 g, 0.44 mmol) in CH3OH (5 mL) and H2O (0.5 mL) is reacted with NaOH (88 mg, 2.2 mmol) at reflux for 2 h. Organic solvent is removed in vacuo, the residue is diluted with H2O, and extracted with Et2O. The aqueous layer is acidified with 5 M HCl, extracted with Et2O, dried with MgSO4, filtered and concentrated to give the title compound as a white solid (72 mg, 77%).
後処理
- temperatureat reflux for 2 h
- customOrganic solvent is removed in vacuo
- additionthe residue is diluted with H2O
- extractionextracted with Et2O
- extractionextracted with Et2O
- dry with materialdried with MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0cfd458d21ff454f8be8868a9f34c742
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07838543B2
反応ノート
読み込み中…