Dimethyl Ether → 3-Methoxy-4-(2-methoxyethoxy)phenylboronic acid
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([B:8]2[O:16]C(C)(C)C(C)(C)[O:9]2)=[CH:4][C:3]=1[O:17][CH3:18].[CH3:19][O:20][CH3:21].[C:22]([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C.CC(OC)(C)C.CCCCCCC>[CH3:18][O:17][C:3]1[CH:4]=[C:5]([B:8]([OH:9])[OH:16])[CH:6]=[CH:7][C:2]=1[O:1][CH2:22][CH2:19][O:20][CH3:21]参加物
6
実験手順
4-Hydroxy-3-methoxyphenylboronic acid pinacol ester (Aldrich, 518786) (1 g; 4 mmol), 2-bromomethyl)-methylether (0.83 g; 6 mmol) and Cs2CO3 (2.6 g; 8 mmol) in DMF (10 ml) are heated to 130° C. for 45 minutes. The reaction mixture is diluted with TBME/heptane (5 ml/5 ml), filtered and evaporated to deliver the title compound as yellow oil used without further purification in Example 79.
後処理
- filtrationfiltered
- customevaporated
- customused without further purification in Example 79
出典と根拠
- ORDレコード
- ord-2162e5bd9a1b4cfdad86ae80be1b76d2
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07838674B2
反応ノート
読み込み中…