(R)-sec-butylamine → (R)-N-sec-butyl-2-(4-(6-cyanopyrazin-2-yl)phenyl)-2-methylpropanamide

反応式

[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([CH3:20])([CH3:19])[C:16]([OH:18])=O)=[CH:11][CH:10]=2)[CH:6]=[N:5][CH:4]=1)#[N:2].[CH3:21][C@@H:22]([NH2:25])[CH2:23][CH3:24]>>[C@H:22]([NH:25][C:16](=[O:18])[C:15]([C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:6]=[N:5][CH:4]=[C:3]([C:1]#[N:2])[N:8]=2)=[CH:14][CH:13]=1)([CH3:20])[CH3:19])([CH2:23][CH3:24])[CH3:21]

参加物

反応物 2

HCID 2724537(R)-sec-butylamine

HCID 687764432-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid

生成物 1

HCID 16005273(R)-N-sec-butyl-2-(4-(6-cyanopyrazin-2-yl)phenyl)-2-methylpropanamide収率 43%

実験手順

Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and (R)-butan-2-amine. Yield 43%.

出典と根拠

ORDレコード: ord-e77ac9e845994dc785bae36886421637
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07842324B2

反応ノート

読み込み中…