Dimethylformamide → HCID 66746413、化合物

HRID 1175755ノート

反応式

HRID 1175755 の反応式
[C:1]12([CH2:9][CH:8](NC(NC3SC4C=C(F)C=CC=4N=3)=O)[C:7]3[CH:24]=[CH:25][CH:26]=[CH:27][C:6]=3[O:5]1)[CH2:4][CH2:3][CH2:2]2.IC.[C:30](=O)([O-])[O-:31].[K+].[K+].CN(C)C=[O:39]>>[CH3:30][O:31][C:25]1[CH:26]=[CH:27][C:6]2[O:5][C:1]3([CH2:2][CH2:3][CH2:4]3)[CH2:9][C:8](=[O:39])[C:7]=2[CH:24]=1

参加物

5

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 16123262HCID 16123262、化合物

生成物 1

HCID 66746413HCID 66746413、化合物

実験手順

To a solution of 3,4-Dihydro-6-hydroxy-4-oxo-spiro[2H-1-benzopyran-2,1′-cyclobutane] (Example 12) (10 mmol) in dimethylformamide, iodomethane (12 mmol) and potassium carbonate (12 mmol) was added and the reaction mixture was stirred at rt for 12 h. Solvent was then evaporated and the residue was dissolved in ethyl acetate. Organic layer was washed with water, brine and separated. It was then dried on anhydrous Na2SO4 and concentrated to afford the desired product as oil.

後処理

  1. customSolvent was then evaporated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washOrganic layer was washed with water, brine
  4. customseparated
  5. dry with materialIt was then dried on anhydrous Na2SO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-0b76445fcbd04a59b47089533712d3f0
出典データセット
uspto-grants-2010_11
特許番号
US07842703B2

反応ノート

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