Sodium borohydride → 6-Chloro-3,4-dihydro-4-hydroxy-spiro[2H-1-benzopyran-2,1'-cyclobutane]
反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[O:15][C:11]3([CH2:14][CH2:13][CH2:12]3)[CH2:10][C:9](=[O:16])[C:8]=2[CH:17]=1>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[O:15][C:11]3([CH2:12][CH2:13][CH2:14]3)[CH2:10][CH:9]([OH:16])[C:8]=2[CH:17]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
Sodium borohydride (40 mmol) was added to a solution of 6-Chloro-3,4-dihydro-4-oxo-spiro[2H-1-benzopyran-2,1′-cyclobutane] (10 mmol) in methanol (10 ml). at about 0° C. and the reaction mixture was stirred at room temperature for about 2 h and compound was extracted in ethyl acetate. Organic layer was washed with water, brine and separated. It was then dried on anhydrous sodium sulfate and concentrated to afford the desired product as a white solid.
後処理
- extractioncompound was extracted in ethyl acetate
- washOrganic layer was washed with water, brine
- customseparated
- dry with materialIt was then dried on anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-83e3f64ff7d3473c9a4e37f6fbdd4e0d
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07842703B2
反応ノート
読み込み中…