2-Amino-5-methylpyridine → 2-Methyl-N-(5-methylpyridin-2-yl)-4-(4-(methylsulfonyl)-phenoxy)-benzofuran-6-carboxamide

HRID 1177251ノート

反応式

HRID 1177251 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[Al](Cl)(C)C.[CH3:13][C:14]1[O:15][C:16]2[CH:22]=[C:21]([C:23](OCC)=[O:24])[CH:20]=[C:19]([O:28][C:29]3[CH:34]=[CH:33][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:31][CH:30]=3)[C:17]=2[CH:18]=1>ClCCCl>[CH3:13][C:14]1[O:15][C:16]2[CH:22]=[C:21]([C:23]([NH:1][C:2]3[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=3)=[O:24])[CH:20]=[C:19]([O:28][C:29]3[CH:30]=[CH:31][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:33][CH:34]=3)[C:17]=2[CH:18]=1

参加物

5

反応物 3

HCID 153482-Amino-5-methylpyridineHCID 79147ChlorodimethylaluminumHCID 59560179Ethyl 2-methyl-4-(4-(methylsulfonyl)phenoxy)benzofuran-6-carboxylate

生成物 1

HCID 667558692-Methyl-N-(5-methylpyridin-2-yl)-4-(4-(methylsulfonyl)-phenoxy)-benzofuran-6-carboxamide収率 86%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

2-Amino-5-methylpyridine (289 mg, 2.67 mmol) was dissolved in DCE (10 mL) at 0° C., then Al(CH3)2Cl (2.67 mL, 1M in hexanes) was added drop wise. After the addition, the ice-bath was removed, and the mixture was stirred for 30 min at room temperature. Ethyl 2-methyl-4-[4-(methylsulfonyl)phenoxy]-1-benzofuran-6-carboxylate (100 mg, 0.267 mmol) was added and the stirring was continued for 14 h. The reaction was quenched with potassium sodium tartrate tetrahydrate (20% w/w) cautiously. The product was extracted with CHCl3, washed with brine and dried over MgSO4. The crude product was purified by gradient silica gel chromatography using CHCl3/MeOH (100/0 to 98/2) to give the title compound (100 mg, 86%) as a white solid. 1H NMR (300 MHz, CHLOROFORM-D) δ ppm 2.32 (s, 3 H) 2.48 (s, 3 H) 3.07 (s, 3 H) 6.24 (s, 1 H) 7.08-7.16 (m, 2 H) 7.48 (d, J=1.32 Hz, 1 H) 7.57 (dd, J=8.29, 2.35 Hz, 1 H) 7.81-7.97 (m, 3 H) 8.12 (d, J=2.35 Hz, 1 H) 8.25 (d, J=8.29 Hz, 1 H) 8.44 (s, 1 H). LCMS for C23H20N2O5S m/z 437.4 (M+H)+.

後処理

  1. additionAfter the addition
  2. customthe ice-bath was removed
  3. waitthe stirring was continued for 14 h
  4. customThe reaction was quenched with potassium sodium tartrate tetrahydrate (20% w/w) cautiously
  5. extractionThe product was extracted with CHCl3
  6. washwashed with brine
  7. dry with materialdried over MgSO4
  8. customThe crude product was purified by gradient silica gel chromatography

出典と根拠

ORDレコード
ord-dfb079e543c143949e7f875de7ce5c4a
出典データセット
uspto-grants-2010_11
特許番号
US07842713B2

反応ノート

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