Hydrochloric Acid → 3-Fluoro-4-(6-(1-phenylcyclopropyl)benzo[d]thiazol-2-yl)benzaldehyde

HRID 1177445ノート

反応式

HRID 1177445 の反応式
[O:1]1CCCO[CH:2]1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[S:14][C:15]3[CH:21]=[C:20]([C:22]4([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[CH2:24][CH2:23]4)[CH:19]=[CH:18][C:16]=3[N:17]=2)=[C:9]([F:31])[CH:8]=1.Cl>C1COCC1>[F:31][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][C:10]=1[C:13]1[S:14][C:15]2[CH:21]=[C:20]([C:22]3([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:23][CH2:24]3)[CH:19]=[CH:18][C:16]=2[N:17]=1)[CH:2]=[O:1]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 671117192-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-6-(1-phenylcyclopropyl)-benzo[d]thiazole

生成物 1

HCID 866387103-Fluoro-4-(6-(1-phenylcyclopropyl)benzo[d]thiazol-2-yl)benzaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

A mixture of 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-6-(1-phenylcyclopropyl)-benzo[d]thiazole (0.061 g, 0.14 mmol) and 5N HCl (3.50 mL, 0.14 mmol) in THF (7.0 mL) was heated to 70° C. for 3 h. The reaction was cooled and concentrated in vacuo, placed in an ice bath, and basified with 5 N aq. NaOH. The solid was collected by filtration, rinsed with water and MeOH, and was dried in vacuo to afford 3-fluoro-4-(6-(1-phenylcyclopropyl)-benzo[d]thiazol-2-yl)benzaldehyde. MS (ESI) m/z: Calculated: 373.1; Observed: 374.0 (M++1).

後処理

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated in vacuo
  3. customplaced in an ice bath
  4. filtrationThe solid was collected by filtration
  5. washrinsed with water and MeOH
  6. customwas dried in vacuo

出典と根拠

ORDレコード
ord-7d7204a4a14d44f9bc45c82c9b37cabb
出典データセット
uspto-grants-2010_11
特許番号
US07842685B2

反応ノート

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