Ethyl 4-bromobutyrate → 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone

HRID 1177636

反応式

HRID 1177636 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH2:26])[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18]1)[N:11]=2.Br[CH2:28][CH2:29][CH2:30][C:31](OCC)=[O:32]>>[F:1][C:2]1[CH:3]=[C:4]([N:26]2[CH2:28][CH2:29][CH2:30][C:31]2=[O:32])[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:18][CH2:19]1)[N:11]=2

参加物

3

反応物 2

HCID 76300Ethyl 4-bromobutyrateHCID 574030523-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine

生成物 1

HCID 591749021-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone

実験手順

3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine (110 mg, 0.304 mmol) was dissolved in ethyl 4-bromobutanoate (59 mg, 0.304 mmol) before it was placed in the microwave for 60 min at 140° C. The title compound was obtained after flash chromatography. MS (ESI) m/z: Calculated: 429.1; Observed: 430.1 (M++1).

出典と根拠

ORDレコード
ord-42bc22b3b49a4a5fa5aa4de3a2b1a162
出典データセット
uspto-grants-2010_11
特許番号
US07842685B2

関連ノート

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