3-Hydroxy-5-nitrobenzotrifluoride → 3-Amino-5-(trifluoromethyl)phenol
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([OH:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)([O-])=O>[OH-].[OH-].[Pd+2].CCOC(C)=O>[NH2:1][C:4]1[CH:5]=[C:6]([OH:14])[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1参加物
4
実験手順
To a solution of 3-Nitro-5-trifluoromethyl-phenol 44 (1.6 g, 7.73 mmol) was added a catalytic amount of 20% palladium hydroxide on carbon and the reaction was stirred under a hydrogen atmosphere (balloon) over the weekend resulting in complete conversion to product by TLC (40% EtOAc:Hexanes). The reaction was filtered to give 3-Amino-5-trifluoromethyl-phenol (1.2 g, 6.76 mmol) as a brown/red oil.
後処理
- filtrationThe reaction was filtered
出典と根拠
- ORDレコード
- ord-210cc58a507849b7a6a845b1c6e87e1c
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07276502B2
反応ノート
読み込み中…