Benzaldehyde → HCID 58696280、化合物

HRID 1178321ノート

反応式

HRID 1178321 の反応式
C(N(CC)CC)C.[CH:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl.[NH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]>C(#N)C>[CH2:22]([O:21][C:19](=[O:20])[CH:18]([N:17]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=1)[CH3:23]

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 6949597672954-97-3

生成物 1

HCID 58696280HCID 58696280、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Triethylamine (170 mL) and benzaldehyde (130 mL) were added to a suspension of ethyl amino-(3,4-dichlorophenyl)-acetate hydrochloride (350 g) in acetonitrile (1.5 L), followed by stirring at room temperature overnight. The insoluble matter was removed through Celite, followed by washing with ethyl acetate. The filtrate was subjected to partitioning with water and then extraction with ethyl acetate. The thus-obtained organic layer was washed with saturated brine, and then dried over sodium sulfate anhydrate. The solvent was removed under reduced pressure, to thereby give the title compound (425 g). The title compound was used in the next step without further purification.

後処理

  1. customThe insoluble matter was removed through Celite
  2. washby washing with ethyl acetate
  3. customto partitioning with water
  4. extractionextraction with ethyl acetate
  5. washThe thus-obtained organic layer was washed with saturated brine
  6. dry with materialdried over sodium sulfate anhydrate
  7. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-05cd4704ccac4b3185bf5dea055323e5
出典データセット
uspto-grants-2007_10
特許番号
US07276511B2

反応ノート

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