Water → 2-Fluoro-4-methoxybenzonitrile
反応式
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:11](=O)([O-])[O-].[K+].[K+].IC.O>CN(C=O)C>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]参加物
6
実験手順
2-Fluoro-4-hydroxybenzonitrile (0.50 g, 3.7 mmol), potassium carbonate (0.53 g, 3.8 mmol) and iodomethane (0.34 mL, 0.78 g, 5.5 mmol) in dry DMF (5 mL) were stirred at ambient temperature for 21 h. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with 1N sodium hydroxide solution (2×), water (3×), brine (1×), and dried over MgSO4. After filtration, the solvent was removed in vacuo to yield 2-fluoro-4-methoxy-benzonitrile (0.54 g, 98%) as a white crystalline solid.
後処理
- extractionextracted with ethyl acetate
- washThe ethyl acetate layer was washed with 1N sodium hydroxide solution (2×), water (3×), brine (1×)
- dry with materialdried over MgSO4
- filtrationAfter filtration
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-349923d992504061b8034fae021a1d19
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07276528B2
反応ノート
読み込み中…