反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].C([O:9][C:10](=O)[CH2:11][C:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[C:20]([O:21][CH3:22])[C:15]=2[O:14][CH:13]=1)C>C1COCC1>[CH3:22][O:21][C:20]1[C:15]2[O:14][CH:13]=[C:12]([CH2:11][CH2:10][OH:9])[C:16]=2[CH:17]=[CH:18][CH:19]=1参加物
4
実験手順
To a stirred suspension of LiAlH4 (200 mg, excess) in THF at 0° C., ethyl(7-methoxy-1-benzofuran-3-yl)acetate (1.17 g, 5 mmol) in THF (20 mL) was added slowly. After the addition, the reaction mixture was stirred at room temperature for 1 hr and quenched with saturated NH4Cl solution. The product was extracted with chloroform and washed well with water. It was dried over anhydrous MgSO4, filtered and concentrated. The product, 2-(7-methoxy-1-benzofuran-3-yl)ethanol, was obtained as a white oil and was pure enough to be taken to the next step without purification. Yield: 800 mg (83%); (M+H): 193.
後処理
- additionAfter the addition
- customquenched with saturated NH4Cl solution
- extractionThe product was extracted with chloroform
- washwashed well with water
- dry with materialIt was dried over anhydrous MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a7fe4c874aaa4e3b88b5410682103812
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07276603B2
関連ノート
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