Ethylamine → 8-(1-Azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole

HRID 1179430ノート

反応式

HRID 1179430 の反応式
[CH2:1]([NH2:3])[CH3:2].[N:4]12[CH2:11][CH2:10][CH:7]([CH2:8][CH2:9]1)[CH:6]([C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH2:21])[CH:19]=3)[NH:14][CH:13]=1)[CH2:5]2>CN(C)C=O.O=[Mn]=O>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11]1)[CH:6]([C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[C:18]4[NH:21][C:1]([CH3:2])=[N:3][C:19]4=3)[NH:14][CH:13]=1)[CH2:5]2

参加物

5

反応物 2

HCID 6341EthylamineHCID 98162073-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indol-5-ylamine

生成物 1

HCID 114488658-(1-Azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6228Dimethylformamide溶媒

実験手順

2 mmol of ethylamine and 10 mmol of MnO2 are added to a solution of 1 mmol of 3-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indol-5-ylamine in 20 ml of dimethylformamide (DMF), and the mixture is stirred at room temperature for 12 hours. The suspension is filtered through Celite and washed with DMF. After the solvent has been distilled, the mixture is subjected to conventional work-up, giving 8-(1-azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole; ESI 281.

後処理

  1. filtrationThe suspension is filtered through Celite
  2. washwashed with DMF
  3. distillationAfter the solvent has been distilled

出典と根拠

ORDレコード
ord-391542ffb6cf467dadec0eb768da4dd3
出典データセット
uspto-grants-2007_10
特許番号
US07279496B2

反応ノート

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