HCID 22047806、化合物 → HCID 178426979、化合物
反応式
C[O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH2:13][C:12]([CH3:17])([CH3:16])[CH2:11][C:10]2=[O:18])=[CH:5][CH:4]=1>O1CCCC1>[OH:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH2:13][C:12]([CH3:16])([CH3:17])[CH2:11][C:10]2=[O:18])=[CH:5][CH:4]=1参加物
3
反応条件
- 温度
- 190 °C
実験手順
6′-Methoxy-4,4-dimethyl-4,5-dihydro-3H-[1,3′]bipyridinyl-2,6-dione (2.56 g, 10.3 m dissolved in a mixture of tetrahydrofuran and diethyl ether. HCl-gas was bubbled into the solution for 5 minutes. More diethyl ether was added and the white precipitate was collected by suction, washed twice with diethyl ether and heated in a kugelrohr apparatus at 190° C. for 15 minutes yielding the title compound (2.16 g, 89% yield) as a white solid.
後処理
- customwas bubbled into the solution for 5 minutes
- additionMore diethyl ether was added
- customthe white precipitate was collected by suction
- washwashed twice with diethyl ether
出典と根拠
- ORDレコード
- ord-3ba61387e2c14910b9264fcf1a718172
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07279470B2
反応ノート
読み込み中…