Diisopropylamine → 4-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179990

反応式

HRID 1179990 の反応式
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[NH:23]1[CH2:28][CH2:27][CH:26]([N:29]2[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=3[N:31]=[N:30]2)[CH2:25][CH2:24]1.C(NC(C)C)(C)C>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:23]3[CH2:24][CH2:25][CH:26]([N:29]4[C:33]5[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=5[N:31]=[N:30]4)[CH2:27][CH2:28]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

参加物

4

反応物 3

HCID 7912DiisopropylamineHCID 27793801-(Piperidin-4-yl)-1H-benzotriazole--hydrogen chloride (1/1)HCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

生成物 1

HCID 695204074-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

実験手順

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-piperidin-4-yl-1 H-benzotriazole, hydrochloride, 5 equivalent of diisopropylamine was added, preparative HPLC (Method C) (7%, colourless crystals). HPLC-MS m/z=506.2 (M+1), Rt: 4.56 min.

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-1a330739b88542b1bd13f7750a486880
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

関連ノート

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