Tyrosol → Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester

HRID 1180048

反応式

HRID 1180048 の反応式
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[CH3:11][N:12]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:13](Cl)=[O:14]>C(Cl)Cl>[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:13](=[O:14])[N:12]([CH3:11])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 10393TyrosolHCID 77969Carbamic chloride, N-methyl-N-phenyl-

生成物 1

HCID 69520342Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester収率 99.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-(2-Hydroxyethyl)phenol (10 mmol) and 4-diazabicyclo[2.2.2]octane (DABCO) (10 mmol) in CH2Cl2 (30 mL) was added N-methyl-N-phenylcarbamoyl chloride (10 mmol). The reaction mixture was stirred for 16 hours at rt, added CH2Cl2 (20 mL), and washed with 1M aqueous HCl and brine. The organic phase was dried (MgSO4) and evaporated to give the 2.69 g (99%) of the title compound as crystals.

後処理

  1. washwashed with 1M aqueous HCl and brine
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-7cb4b87fd2f641f0985c21c6fa665b9f
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

関連ノート

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