Benzoic Acid → Rizatriptan Benzoate

HRID 1180101

反応式

HRID 1180101 の反応式
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:10][N:11]([CH2:13][CH2:14][C:15]1[C:19]2[CH:20]=[C:21]([CH2:24][N:25]3[N:29]=[CH:28][N:27]=[CH:26]3)[CH:22]=[CH:23][C:18]=2[NH:17][CH:16]=1)[CH3:12]>C(OC(C)C)(=O)C.C(O)(C)C>[CH3:10][N:11]([CH2:13][CH2:14][C:15]1[C:19]2[CH:20]=[C:21]([CH2:24][N:25]3[N:29]=[CH:28][N:27]=[CH:26]3)[CH:22]=[CH:23][C:18]=2[NH:17][CH:16]=1)[CH3:12].[CH:5]1[CH:4]=[CH:3][C:2]([C:1]([OH:9])=[O:8])=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 243Benzoic AcidHCID 5078Rizatriptan

生成物 1

HCID 77997Rizatriptan Benzoate収率 80.1%

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 7915Isopropyl Acetate溶媒

実験手順

A solution of 147 mg (1.2 mmoles) of benzoic acid in 1 ml of isopropyl acetate was added slowly to a solution of 300 mg (1.1 mmoles) of the rizatriptan base in 2.6 ml of isopropyl alcohol. The mixture was stirred at room temperature for 30 minutes and evaporated to dryness, and the residue recrystallised from ethanol to give 345 mg (80%) of rizatriptan benzoate as a white crystalline solid.

後処理

  1. customevaporated to dryness
  2. customthe residue recrystallised from ethanol

出典と根拠

ORDレコード
ord-abd210887dcd46259279e7ded4ab972d
出典データセット
uspto-grants-2007_10
特許番号
US07279581B2

関連ノート

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