Methanol → 2-[(4-{[4-(Tert-butoxycarbonyl)piperazin-1-yl]carbonyl}phenyl)(phenyl)methoxy]-4-methylpentanoic acid potassium salt

HRID 1180379ノート

反応式

HRID 1180379 の反応式
C[O:2][C:3]([CH:5]([O:10][CH:11]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:12]1[CH:32]=[CH:31][C:15]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)=[O:17])=[CH:14][CH:13]=1)[CH2:6][CH:7]([CH3:9])[CH3:8])=[O:4].CO.[OH-].[K+:42]>C1COCC1>[K+:42].[C:27]([O:26][C:24]([N:21]1[CH2:22][CH2:23][N:18]([C:16]([C:15]2[CH:31]=[CH:32][C:12]([CH:11]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[O:10][CH:5]([CH2:6][CH:7]([CH3:8])[CH3:9])[C:3]([O-:4])=[O:2])=[CH:13][CH:14]=2)=[O:17])[CH2:19][CH2:20]1)=[O:25])([CH3:29])([CH3:30])[CH3:28]

参加物

5

反応物 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 69473035Tert-butyl 4-{4-[[1-(methoxycarbonyl)-3-methylbutoxy](phenyl)methyl]benzoyl}piperazine-1-carboxylate

生成物 1

HCID 694738852-[(4-{[4-(Tert-butoxycarbonyl)piperazin-1-yl]carbonyl}phenyl)(phenyl)methoxy]-4-methylpentanoic acid potassium salt

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

To a solution of tert-butyl 4-{4-[[1-(methoxycarbonyl)-3-methylbutoxy](phenyl)methyl]benzoyl}piperazine-1-carboxylate from step 3 (0.6 g, 1.1 mmol) in THF (6.5 mL) was added methanol (2.2 mL) and 1.0N aqueous potassium hydroxide solution (2.2 mL, 2.2 mmol). The mixture was heated at 70° C. for 20 minutes and then cooled down to room temperature. The crude mixture was evaporated under reduced pressure and co-evaporated twice with toluene. The solid residue obtained was used as such in the next step.

後処理

  1. temperaturecooled down to room temperature
  2. customThe crude mixture was evaporated under reduced pressure
  3. customThe solid residue obtained

出典と根拠

ORDレコード
ord-f2ef7583725840fe84541965e437bcfe
出典データセット
uspto-grants-2007_10
特許番号
US07279478B2

反応ノート

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