1-(Aminomethyl)cyclohexan-1-ol → 1-Oxa-3-azaspiro(4.5)decan-2-one
反応式
[NH2:1][CH2:2][C:3]1([OH:9])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:10]([O:14]C(OC(OC(C)(C)C)=O)=O)(C)(C)C>CN(C)C1C=CN=CC=1.C(#N)C.C(O)(=O)C.Cl>[O:9]1[C:3]2([CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2][NH:1][C:10]1=[O:14]参加物
7
実験手順
0.65 g (5.0 mmol) of 1-(aminomethyl)-cyclohexanol, 1.2 g (5.5 mmol) di-tert.-butyldicarbonate ((Boc)2O) and 0.611 g 4-dimethylaminopyridine were dissolved in 50 ml acetonitrile and agitated overnight at room temperature. The mixture was then fully turned over, the residue was dissolved in 20 ml acetic acid and again turned over. The residue was taken up in 25 ml 1 M hydrochloric acid and extracted with 50 ml toluene.
後処理
- extractionextracted with 50 ml toluene
出典と根拠
- ORDレコード
- ord-7ac8cd96d6e54722932bd77cad796e30
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07282515B2
反応ノート
読み込み中…