Sodium Hydroxide → 2-(2-Ethylsulfanyl-1-hydroxy-1-methyl-ethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile

HRID 1180606ノート

反応式

HRID 1180606 の反応式
[CH2:1]([S:3][CH2:4][C:5]([C:8]1[N:9](S(C)(=O)=O)[C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([C:17]#[N:18])=[C:12]([C:19]([F:22])([F:21])[F:20])[CH:11]=2)([OH:7])[CH3:6])[CH3:2].[OH-].[Na+]>>[CH2:1]([S:3][CH2:4][C:5]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([C:17]#[N:18])=[C:12]([C:19]([F:21])([F:20])[F:22])[CH:11]=2)([OH:7])[CH3:6])[CH3:2]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 668656012-(2-ethylsulfanyl-1-hydroxy-1-methyl-ethyl)-1-methanesulfonyl-6-trifluoromethyl-1H-indole-5-carbonitrile

生成物 1

HCID 117096572-(2-Ethylsulfanyl-1-hydroxy-1-methyl-ethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile

実験手順

This compound was prepared using the general de-protection procedure as describe in General Procedures Example B, reacting 2-(2-ethylsulfanyl-1-hydroxy-1-methyl-ethyl)-1-methanesulfonyl-6-trifluoromethyl-1H-indole-5-carbonitrile (219 mg, 0.54 mmol) and using 4M sodium hydroxide (0.40 mL, 1.62 mmol) as the base, to yield the title compound as a white solid.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-eccd2f7d83d54d3db48ff1b1c30e4e6f
出典データセット
uspto-grants-2007_10
特許番号
US07282507B2

反応ノート

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