Indane → Indan-5-sulfonyl chloride
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[Cl:10][S:11](O)(=[O:13])=[O:12]>ClCCl>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([S:11]([Cl:10])(=[O:13])=[O:12])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1参加物
4
実験手順
To a solution of indane (50 mmol, 6.11 mL) in dichloromethane (50 ml) at 0° C. is added dropwise chlorosulfonic acid (200 mmol, 13.3 ml). The resulting solution is allowed to return to room temperature and is stirred for 2 hr. The solution is then poured slowly onto a mixture of ice (200 g) and dichloromethane (50 ml). The organic layer is separated, washed with brine (50 mL), dried over sodium sulfate, filtered and evaporated to produce indan-5-sulfonic acid chloride.
後処理
- customto return to room temperature
- customThe organic layer is separated
- washwashed with brine (50 mL)
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-f531ef2c48b4430da25b6d43132e028e
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07282595B2
反応ノート
読み込み中…