Phosgene → (1-benzylcyclobutyl)methyl(1S)-1-(1-hydroxy-2-oxo-2-{[(1r)-1-phenylethyl]amino}ethyl)pentylcarbamate

HRID 1180737

反応式

HRID 1180737 の反応式
C([CH:3]([C:5]1([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][CH2:6]1)[OH:4])C.[C:16](Cl)(Cl)=[O:17].[NH2:20][C@@H:21]([CH2:35][CH2:36][CH2:37][CH3:38])[CH:22]([OH:34])[C:23]([NH:25][C@@H:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH3:27])=[O:24].C(N(CC)CC)C>O1CCCC1.C1(C)C=CC=CC=1.C(OCC)(=O)C>[OH:34][CH:22]([C@@H:21]([NH:20][C:16](=[O:17])[O:4][CH2:3][C:5]1([CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:7][CH2:8]1)[CH2:35][CH2:36][CH2:37][CH3:38])[C:23](=[O:24])[NH:25][C@@H:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH3:27]

参加物

8

反応物 4

HCID 6371PhosgeneHCID 8471TriethylamineHCID 11265560(3S)-3-amino-2-hydroxy-N-[(1R)-1-phenylethyl]heptanamideHCID 69240190Ethyl(1-benzylcyclobutyl)methanol

生成物 1

HCID 58979674(1-benzylcyclobutyl)methyl(1S)-1-(1-hydroxy-2-oxo-2-{[(1r)-1-phenylethyl]amino}ethyl)pentylcarbamate収率 99.7%

試薬・触媒・溶媒 3

HCID 1140Toluene溶媒HCID 8028Tetrahydrofuran溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 100 mg (0.57 mmol) of ethyl (1-benzylcyclobutyl)methanol in 3 mL of tetrahydrofuran was added 0.68 mL (1.31 mmol) of 1.93 M phosgene in toluene in one portion. The reaction was stirred overnight at room temperature. The mixture was concentrated under vacuum. The remaining oil was dissolved in 1 mL tetrahydrofuran and added to a solution of 136 mg (0.516 mmol) of (3S)-3-amino-2-hydroxy-N-[(1R)-1-phenylethyl]heptanamide and 0.079 mL (0.568 mmol) of triethylamine in 5 mL tetrahydrofuran. The reaction was stirred at room temperature for 3 h, diluted with ethyl acetate, and washed with 1M hydrochloric acid. The organic phase was washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure to afford 240 mg (99%) of (1-benzylcyclobutyl)methyl(1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate. 1H NMR (300 MHz, DMSO-d6) δ 8.07 (d, J=9 Hz, 1H), 7.17-7.36 (m, 10H), 6.57 (d, J=9 Hz, 1H), 5.57 (d, J=6 Hz, 1H), 4.90-5.02 (m, 1H), 3.89-3.94 (m, 1H), 3.75-3.84 (m, 3H), 2.77 (s, 2H), 1.70-1.93 (m, 6H), 1.25-1.53 (m, 9H), 0.88 (t, J=7 Hz, 3H). ES-LCMS m/z 489 (M+Na).

後処理

  1. concentrationThe mixture was concentrated under vacuum
  2. dissolutionThe remaining oil was dissolved in 1 mL tetrahydrofuran
  3. stirringThe reaction was stirred at room temperature for 3 h
  4. washwashed with 1M hydrochloric acid
  5. washThe organic phase was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f45c69f0bab24612be8ada08b397c36a
出典データセット
uspto-grants-2007_10
特許番号
US07282512B2

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