Dimethylamine → N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

反応式

[Br:1][C:2]1[C:3]([C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)=[N:4][N:5]([CH2:7][CH3:8])[CH:6]=1.[CH3:16][NH:17][CH3:18].[O:19]1[CH2:23]CCC1>>[Br:1][C:2]1[C:3]([C:9]2[CH:15]=[CH:14][C:12]([NH:13][C:23](=[O:19])[N:17]([CH3:18])[CH3:16])=[CH:11][CH:10]=2)=[N:4][N:5]([CH2:7][CH3:8])[CH:6]=1

参加物

反応物 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 68995309HCID 68995309、化合物

生成物 1

HCID 68999367N'-[4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea

実験手順

Following the procedure described in Example 5a with 4-(4-bromo-1-ethyl-1H-pyrazol-3-yl)aniline and 2 M dimethylamine in tetrahydrofuran provided the title compound. ESMS [M+H]+: 337.2

出典と根拠

ORDレコード: ord-a3f8982e33f44f219470ed702ec0f967
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07282588B2

反応ノート

読み込み中…