Benzoylacetone → 3-Methyl-5-phenyl-1H-pyrazole
反応式
O.[NH2:2][NH2:3].[C:4]([CH2:12][C:13](=O)[CH3:14])(=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C>[CH3:14][C:13]1[NH:3][N:2]=[C:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:12]=1参加物
4
実験手順
Hydrazine hydrate (9.0 mL, 99 mmol, 35 wt. % in H2O; 0.64 equiv) was added to a solution of benzoylacetone (25.00 g, 154.1 mmol, 1 equiv) in ethanol (250 mL). After stirring 14 h, more hydrazine hydrate (8.0 mL, 88 mmol, 0.57 equiv) was added. After 2 h, the reaction solution was concentrated (95° C.) to give the title compound as a white solid (24.31 g, 99.7%). HRMS Calculated for C10H11N2: m/z 159.0922. Found: 159.0917.
後処理
- waitAfter 2 h
- concentrationthe reaction solution was concentrated (95° C.)
出典と根拠
- ORDレコード
- ord-02ef0defa7804f39892c51bcd55547a5
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07282501B2
反応ノート
読み込み中…