Hydrazine hydrate (1:1) → (7-Methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride
反応式
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:1].[CH3:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:13][NH2:14])[C:3]=2[S:10][CH:9]=1参加物
4
実験手順
A suspension of 4-chloro-7-methylthieno[3,2-d]pyrimidine (4, 3.1 g, 17 mmol) and hydrazine monohydrate (3.5 mL, 72 mmol) in ethanol (34 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (3.2 g, 88% yield) as a white solid.
後処理
- temperaturewas heated
- temperatureat reflux for 1 hour
- filtrationthe solid product was collected by vacuum filtration
出典と根拠
- ORDレコード
- ord-39a22508340f48f6a4f3eb4aa3f801b3
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285556B2
反応ノート
読み込み中…