Ammonium formate → 3H,4H-thieno[3,2-d]pyrimidin-4-one

HRID 1181274ノート

反応式

HRID 1181274 の反応式
C([O-])=O.[NH4+:4].C[O:6][C:7]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[NH:14][CH:15]=O)=O>C(N)=O>[N:14]1[C:13]2[CH:12]=[CH:11][S:10][C:9]=2[C:7](=[O:6])[NH:4][CH:15]=1

参加物

4

反応物 2

HCID 2723923Ammonium formateHCID 2777636Methyl 3-(formylamino)-2-thiophenecarboxylate

生成物 1

HCID 1354174223H,4H-thieno[3,2-d]pyrimidin-4-one収率 63.4%

試薬・触媒・溶媒 1

HCID 713Formamide溶媒

反応条件

温度
150 °C

実験手順

To a solution of ammonium formate (9.4 g, 0.15 mol) in formamide (14 mL) at 150° C. was added 3-(formylamino)-2-thiophenecarboxylic acid methyl ester (81, 5.2 g, 28 mmol) as a solid in small portions. The resulting solution was heated at 150° C. for 4 hours and then allowed to stand at room temperature for 12 hours. The precipitate that formed was collected by vacuum filtration to give 3H-thieno[3,2-d]pyrimid-4-one (2.7 g, 63% yield) as white needles.

後処理

  1. customThe precipitate that formed
  2. filtrationwas collected by vacuum filtration

出典と根拠

ORDレコード
ord-b0aa797d4a7d491982a130632bfc22bf
出典データセット
uspto-grants-2007_10
特許番号
US07285556B2

反応ノート

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