8-fluoro-5-nitroisoquinoline → 8-Fluoroisoquinolin-5-amine

HRID 1181403ノート

反応式

HRID 1181403 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-])=O)=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.[H][H]>CO.[Pd]>[F:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([NH2:12])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 670018188-fluoro-5-nitroisoquinolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 450907648-Fluoroisoquinolin-5-amine収率 40.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a nitrogen flushed solution of 8-fluoro-5-nitroisoquinoline (Description 42; 1.33 g, 6.9 mmol) in methanol (100 ml) was added 10% palladium on carbon (500 mg) and the resulting mixture stirred under a balloon of hydrogen for 3.5 hours. The catalyst was removed by filtration and the filtrate evaporated to dryness. The residue was purifted by MPLC (Biotage Flash™ 40) eluting with 2% MeOH in dichloromethane to give the title compound (450 mg, 40%) as a yellow solid.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated to dryness
  3. washeluting with 2% MeOH in dichloromethane

出典と根拠

ORDレコード
ord-8da809e3d33542c9a8a9991cf753f64a
出典データセット
uspto-grants-2007_10
特許番号
US07285563B2

反応ノート

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