Nitric Acid → 2-Hydroxy-5-methoxy-3-nitrobenzaldehyde

HRID 1181421ノート

反応式

HRID 1181421 の反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:7]([CH:8]=[O:9])[C:6]([OH:11])=[CH:5][CH:4]=1.[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C>[OH:11][C:6]1[C:5]([N+:12]([O-:14])=[O:13])=[CH:4][C:3]([O:2][CH3:1])=[CH:10][C:7]=1[CH:8]=[O:9]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 956952-Hydroxy-5-methoxybenzaldehyde

生成物 1

HCID 5222182-Hydroxy-5-methoxy-3-nitrobenzaldehyde収率 69%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 5-methoxysalicylaldehyde (22.52 g; 148 mmol) in acetic acid (120 ml) was added dropwise over 1 hour a mixture of fuming nitric acid (7.1 ml) in acetic acid (25 ml). After complete addition the mixture was stirred at room temperature for 5 hours. The precipitate was removed by filtration, washed with ethanol and dried to give the title compound (20.3 g, 69%) as a bright yellow solid.

後処理

  1. additionAfter complete addition the mixture
  2. customThe precipitate was removed by filtration
  3. washwashed with ethanol
  4. customdried

出典と根拠

ORDレコード
ord-69fec011ec534f2db039805e3dcc0f21
出典データセット
uspto-grants-2007_10
特許番号
US07285563B2

反応ノート

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