Water → 1-[2-(Trifluoromethyl)pyrimidin-5-yl]methanamine
反応式
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][CH:10]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>C1COCC1>[NH2:1][CH2:4][C:5]1[CH:6]=[N:7][C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][CH:10]=1参加物
5
実験手順
To a solution of 5-(azidomethyl)-2-(trifluoromethyl)pyrimidine (Description 120; 660 mg, 3.26 mmol) in anhydrous THF (10 ml) was added triphenylphosphine (1.71 g, 6.52 mmol) and water (0.059 ml, 3.26 mmol) and the resulting mixture stirred at room temperature overnight. The mixture was evaporated and the residue purified by column chromatography on silica elution with 5% MeOH in DCM+0.5% NH4OH to give the title compound (320 mg, 55%) as a pale yellow solid.
後処理
- customThe mixture was evaporated
- customthe residue purified by column chromatography on silica elution with 5% MeOH in DCM+0.5% NH4OH
出典と根拠
- ORDレコード
- ord-64469a26665d4d448894d148df3eac04
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285563B2
反応ノート
読み込み中…