Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione
反応式
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1)[NH2:3]参加物
4
実験手順
Hydrazine hydrate (5.9 ml) was added to a solution of 6-chloro-1-isobutylpyrimidine-2,4(1H,3H)-dione synthesized according to procedure described in Heterocycles, 1990, 31(9), 1641-1646, (5.9 g) in ethanol (100 ml). The mixture was heated at reflux for 16 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was crystallized from ethanol to give the subtitle compound (5.8 g).
後処理
- customsynthesized
- temperatureThe mixture was heated
- temperatureat reflux for 16 hours
- customevaporated under reduced pressure
- customThe residue was crystallized from ethanol
出典と根拠
- ORDレコード
- ord-1f7001115b7e4bd986db5fa5ead6b051
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285558B2
反応ノート
読み込み中…