Tributylamine → Clodronate

HRID 1181911

反応式

HRID 1181911 の反応式
[Na+].[Na+].[Cl:3][C:4]([Cl:13])([P:9](=[O:12])([O-:11])[O-:10])[P:5](=[O:8])([OH:7])[OH:6].C(N(CCCC)CCCC)CCC>>[Cl:13][C:4]([Cl:3])([P:5](=[O:6])([OH:8])[OH:7])[P:9](=[O:10])([OH:11])[OH:12]

参加物

3

反応物 2

HCID 7622TributylamineHCID 73554303Dichloromethylenediphosphonic acid

生成物 1

HCID 25419Clodronate

実験手順

An aqueous solution of dichloromethylenediphosphonic acid disodium salt (1.0 g, 3.46 mmol) was loaded on a column of DOWEX 50WX8-100 ion-exchange resin and eluted with water. Tributylamine (1.65 mL, 6.92 mmol) was added and the mixture was shaken vigorously. The resulting solution was concentrated to dryness and coevaporated with anhydrous DMF three times. The residue was dried under vacuum overnight.

後処理

  1. washeluted with water
  2. concentrationThe resulting solution was concentrated to dryness
  3. customThe residue was dried under vacuum overnight

出典と根拠

ORDレコード
ord-b00d9609df3e4f67bd077843cb0cb932
出典データセット
uspto-grants-2007_10
特許番号
US07285658B2

関連ノート

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