Trifluoroacetic acid → 3-(3-(4-Chlorobenzyl)azetidin-1-yl)propan-1-amine

HRID 1182100ノート

反応式

HRID 1182100 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:14][CH:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:12]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][CH:13]2[CH2:14][N:11]([CH2:10][CH2:9][CH2:8][NH2:7])[CH2:12]2)=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69411053{3-[3-(4-Chloro-benzyl)-azetidin-1-yl]-propyl}carbamic acid tert-butyl ester

生成物 1

HCID 694091233-(3-(4-Chlorobenzyl)azetidin-1-yl)propan-1-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of {3-[3-(4-chloro-benzyl)-azetidin-1-yl]-propyl}-carbamic acid tert-butyl ester (0.48 g, 1.43 mmol) in DCM (5 ml) is treated with trifluoroacetic acid (2 ml) and the reaction mixture stirred for 1.25 hours. The solvent is evaporated and the crude product partitioned between 1 M sodium hydroxide solution and 20% isopropanol in DCM. The organic phase is evaporated to afford 3-[3-(4-chloro-benzyl)-azetidin-1-yl]-propylamine. [M+H] 239.13.

後処理

  1. customThe solvent is evaporated
  2. customthe crude product partitioned between 1 M sodium hydroxide solution and 20% isopropanol in DCM
  3. customThe organic phase is evaporated

出典と根拠

ORDレコード
ord-30d854ffd4d44fbcabb1be1be1dc836c
出典データセット
uspto-grants-2007_10
特許番号
US07288537B2

反応ノート

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