Hydroxyamine hydrochloride → HCID 23072466、化合物

HRID 1182471ノート

反応式

HRID 1182471 の反応式
[C:1]1([C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:22][OH:23].Cl>C(N(CC)CC)C>[OH:23][NH:22][C:19](=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:12]

参加物

4

反応物 2

HCID 443297Hydroxyamine hydrochlorideHCID 230724738-(1-Naphthyl)-8-oxooctanoic acid

生成物 1

HCID 23072466HCID 23072466、化合物収率 58%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

Following the procedure described in Example 14, step 3, but substituting carboxylic acid 50f for 37 and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound was obtained as light yellow solid in 58% yield: 1H NMR (300 MHz, CD3OD/CDCl3=5/1) δ 8.50 (d, J=8.1 Hz, 1H), 7.40-7.90 (m, 6H), 2.93(t, J=7.5 Hz, 2H), 2.12 (m, 2H), 1.69 (m, 2H), 1.59 (m, 2H), 1.30 (m, 4H); 13C NMR (75.4 MHz, CD3OD/CDCl3=5/1) δ 24.27, 25.08, 28.63(2), 32.65, 41.88, 124.29, 125.53, 126.27, 127.33, 127.70, 128.30, 129.91, 132.32, 133.77, 135.91, 171.87, 205.28.

出典と根拠

ORDレコード
ord-57fe9b414660430e917dad20c1c5681b
出典データセット
uspto-grants-2007_10
特許番号
US07288567B2

反応ノート

読み込み中…