Ammonium Chloride → HCID 58118555、化合物
反応式
[Na].[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]#[N:10])[C:4]=1[NH:11][CH2:12][C:13]([NH2:15])=[O:14].[NH4+].[Cl-]>CC(O)C>[NH2:10][C:9]1[C:5]2[C:4](=[C:3]([Br:2])[CH:8]=[CH:7][CH:6]=2)[NH:11][C:12]=1[C:13]([NH2:15])=[O:14]参加物
5
反応条件
- 温度
- 0 °C
実験手順
1.17 g (50.9 mmol) sodium was dissolved in 150 ml 2-propanol. Then, 10.82 g (42.6 mmol) 2-(2-bromo-6-cyano-phenylamino)acetamide was added and the solution was refluxed for 15 min. Thereafter, the reaction mixture was cooled to 0° C. and saturated NH4Cl solution was added. The solvent was concentrated, the resulting precipitate was sucked off and washed with water. 8.6 g (79%) 3-amino-7-bromo-1H-indole-2-carboxylic acid amide was obtained. ESI-MS [m/z]: 254, 256 [M+H]+
後処理
- temperaturethe solution was refluxed for 15 min
- concentrationThe solvent was concentrated
- washwashed with water
出典と根拠
- ORDレコード
- ord-9cb455f558d049af9bf991a3ddac2882
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664233B2
反応ノート
読み込み中…