Hydrazine hydrate (1:1) → ((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

HRID 1183020ノート

反応式

HRID 1183020 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 66917015[(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

生成物 1

HCID 86651886((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of [(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (2.80 g, 8.42 mmol) and hydrazine monohydrate (3.0 mL, 60.0 mmol) in EtOH (50 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is collected by filtration and washed with DCM to afford the crude product as a white solid that is used without further purification.

後処理

  1. filtrationThe precipitated solid is collected by filtration
  2. washwashed with DCM

出典と根拠

ORDレコード
ord-fe409e3bf567465a909fe71aac508a74
出典データセット
uspto-grants-2014_03
特許番号
US08664228B2

反応ノート

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