Dimethylformamide → HCID 86676960、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([C:15]([OH:17])=O)=[N:9]1.CN(C=O)C.C(Cl)(=O)C([Cl:26])=O>CC1CCCO1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([C:15]([Cl:26])=[O:17])=[N:9]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
A suspension of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid (39.1 g, 167 mmol) in 2-methyltetrahydrofuran (300 ml) was cooled to 0° C. and DMF (293 μl, 3.81 mmol) was added. Oxalyl chloride (23.1 g, 182 mmol) was added dropwise. After 16 h at room temperature ca. 100 ml of the solvent were removed by distillation. The resulting suspension of the title compound was used directly in the next step.
後処理
- customAfter 16 h at room temperature ca. 100 ml of the solvent were removed by distillation
- additionThe resulting suspension of the title compound
出典と根拠
- ORDレコード
- ord-a454ab17f14d44268d8fa2be4f851fa8
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664257B2
反応ノート
読み込み中…