Cesium carbonate → HCID 67363573、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([OH:13])=[CH:11][C:10]([C:14]([OH:16])=[O:15])=[N:9]1.C(=O)([O-])[O-].[Cs+].[Cs+].[N:23]1([C:28](Cl)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]1>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([O:13][C:28]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:29])=[CH:11][C:10]([C:14]([OH:16])=[O:15])=[N:9]1参加物
5
反応条件
- 温度
- 50 °C
実験手順
150 mg (0.675 mmol) of 1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid were dissolved in 5 ml of THF. 440 mg (1.35 mmol) of cesium carbonate and 90.2 mg (0.675 mmol) of pyrrolidine-1-carbonyl chloride were added and the mixture was heated to 50° C. for 4 h. Then the mixture was filtrated and the filtrate containing the title compound directly used in the next step.