Hydrochloric Acid → HCID 67361832、化合物
反応式
C[O:2][C:3]([C:5]1[C:9]([F:10])=[C:8]([O:11][CH3:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[N:6]=1)=[O:4].[OH-].[Li+].O.Cl>O1CCOCC1>[F:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[C:8]=1[O:11][CH3:12]参加物
6
反応条件
- 温度
- 56 °C
実験手順
70 mg (0.26 mmol) of 4-fluoro-1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 1.3 ml of dioxane and 1.305 ml of a 1 M aqueous solution of lithium hydroxide were added. The mixture was stirred at 56° C. for 30 min, then water and 2 N hydrochloric acid were added and the mixture extracted with diethyl ether. The organic phase was evaporated to give 67 mg (33%) of the title compound.
後処理
- extractionthe mixture extracted with diethyl ether
- customThe organic phase was evaporated
出典と根拠
- ORDレコード
- ord-1c4d408a7dc94d12b67bc7c1c783f33f
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664257B2
反応ノート
読み込み中…