Lithium Hydroxide → HCID 67363376、化合物
反応式
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH2:11][C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[N:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[N:6]=1)=[O:4].[OH-].[Li+]>O>[CH3:14][C:13]([CH3:16])([CH3:15])[C:12](=[O:17])[CH2:11][O:10][C:8]1[N:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=1参加物
4
実験手順
100 mg (0.3 mmol) of 5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 5 ml of MOH. 0.7 mmol of lithium hydroxide and 2 ml of water were added and the mixture stirred overnight at room temperature. The solvent was removed in vacuo and the residue subjected to aqueous work-up with a 10% solution of citric acid and DCM. The organic phase was dried and the solvent removed in vacuo to give the title compound.