Sodium borohydride → HCID 67362472、化合物
反応式
[CH3:1][C:2]([CH3:35])([CH3:34])[C:3](=[O:33])[CH2:4][O:5][C:6]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[N:9]=[C:8]([C:18]([NH:20][C@H:21]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH2:22][C:23]([OH:25])=[O:24])=[O:19])[CH:7]=1.[BH4-].[Na+]>C(Cl)Cl>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N:10]1[C:6]([O:5][CH2:4][CH:3]([OH:33])[C:2]([CH3:35])([CH3:34])[CH3:1])=[CH:7][C:8]([C:18]([NH:20][C@H:21]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH2:22][C:23]([OH:25])=[O:24])=[O:19])=[N:9]1参加物
4
実験手順
50 mg (0.1 mmol) of (S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid were dissolved in 5 ml of DCM and 0.05 mmol of sodium borohydride were added. The mixture was stirred at room temperature overnight. The solvent was removed in vacuo and the residue subjected to preparative HPLC to given 52% of the title compound.