[1-(4'-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester → [1-(4'-{4-[4-(4-Benzyl-phenyl)-1-hydroxy-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

HRID 1183330ノート

反応式

HRID 1183330 の反応式
[CH2:1]([O:3][C:4](=[O:45])[CH2:5][C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH:27]([OH:44])[CH2:28]/[CH:29]=[CH:30]/[C:31]4[CH:36]=[CH:35][C:34]([CH2:37][C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)=[CH:33][CH:32]=4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:45])[CH2:5][C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[CH:27]([OH:44])[CH2:28][CH2:29][CH2:30][C:31]4[CH:36]=[CH:35][C:34]([CH2:37][C:38]5[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=5)=[CH:33][CH:32]=4)=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:8][CH2:7]1)[CH3:2]

参加物

4

反応物 1

HCID 66581235[1-(4'-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

生成物 1

HCID 66577652[1-(4'-{4-[4-(4-Benzyl-phenyl)-1-hydroxy-butyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

[1-(4′-{4-[(E)-4-(4-Benzyl-phenyl)-1-hydroxy-but-3-enyl]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropyl]-acetic acid ethyl ester (0.203 g, 0.340 mmol) was dissolved in EtOH and palladium on carbon (0.020 g, 10% wt., wet: 50% w/w H2O) was added. The reaction was stirred under H2 (g) atmosphere overnight then filtered through Celite to afford the title compound in EtOH solution, which was brought to the next step without further purification.

後処理

  1. filtrationthen filtered through Celite

出典と根拠

ORDレコード
ord-6ce1e928f1c84a6db52c566d44272fb6
出典データセット
uspto-grants-2014_03
特許番号
US08664220B2

反応ノート

読み込み中…